LSPRi Biosensing – High-throughput Label-free Diagnostics of the Future?

Attila Bonyár, IEEE Senior Member

Department of Electronics Technology, Faculty of Electrical Engineering and Informatics, Budapest University of Technology and Economics, Budapest, Hungary; bonyar@ett.bme.hu

Abstract

In the past couple of decades, the development of plasmonic nanosensors underwent rapid progress, both in the fields of fabrication, integration, and realized applications. Localized surface plasmon resonance imaging (LSPRi) promises the possibility of high-throughput biomolecule sensing integrated into miniaturized point-of-care (PoC) devices. This article provides an overview of the working principle of LSPRi devices and discusses the key requirements for nanoplasmonic sensors elements to realize these goals. The possibilities and limitations of available nanofabrication technologies are also discussed.